Data Sheet 1_Glucagon-like peptide-1 receptor agonists and advanced liver outcomes in type

A systematic review and meta-analysis of 12 real-world cohort studies investigating the effect of GLP-1 receptor agonists on advanced liver outcomes in adults with type 2 diabetes. The primary pooled estimate from four active-comparator studies was a hazard ratio of 0.85 (95% CI 0.74–0.98) for incident cirrhosis or serious liver events. Authored by Jing-Hong Hu and last updated in June 2026, the work is registered with PROSPERO (CRD420261299499) and shared under a CC-BY-4.0 license.

Use Cases

• Assessing the association between GLP-1RA use and advanced liver disease based on real-world comparative cohort studies.
• Evaluating methodological approaches for causal inference in observational pharmacoepidemiology based on the described active-comparator designs.
• Supporting hypothesis generation for future clinical trials on GLP-1RAs and liver outcomes based on the pooled hazard ratio signal.
• Teaching systematic review methodology using a documented example with a focused search strategy and explicit evidence-identification limits.

Strengths

• Includes 12 eligible comparative studies identified through a systematic search of PubMed/MEDLINE and Embase.
• Reports a specific pooled hazard ratio (HR 0.85) with confidence intervals from a meta-analysis of four studies.
• Employs a predefined analytical stratum focusing on active-comparator (DPP-4 inhibitors) designs to improve exchangeability.

Limitations

• The dataset is a single 18.8 KB DOCX document, indicating a very limited scope and scale of raw data.
• Column-level documentation is absent; field semantics must be inferred after download.
• The authors rated the certainty of evidence as 'very low' due to the observational nature of included studies and potential for residual confounding.

Provenance

Source

figshare, authored by Jing-Hong Hu.

Collection Method

Systematic review and exploratory meta-analysis of peer-reviewed comparative real-world cohort studies.

Time Range

Literature search updated through 25 April 2026.

Freshness

Last updated 2026-06-02 04:21:24.