Glutathione Peroxidase 2 Expression in 18,555 Human Tumor Samples

18,555 tumor samples from 148 different tumor types were analyzed for GPX2 expression via immunohistochemistry on tissue microarrays. The dataset, authored by Viktoria Chirico and last updated in May 2026, shows GPX2 positivity was most frequent in colorectal, urothelial, and pancreatico-biliary cancers, and links reduced expression to features of aggressive disease.

Use Cases

• Identifying tumor types with high GPX2 expression based on the 148 categories analyzed.
• Investigating correlations between reduced GPX2 staining and aggressive disease features like metastasis and microsatellite instability.
• Comparing biomarker prevalence across cancer entities derived from normal cell types with high GPX2 expression.

Strengths

• Large sample size of 18,555 tumors provides broad coverage.
• Analysis spans 148 distinct tumor categories, enabling comparative studies.
• Statistical links to clinical parameters like pT stage and metastasis are reported.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying data table is unknown, which may limit suitability assessment.
• The primary data file is a DOCX document, which may require extraction to access structured data.

Provenance

Source

figshare, authored by Viktoria Chirico.

Collection Method

Immunohistochemistry analysis on tissue microarrays.

Time Range

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Freshness

Last updated 2026-05-04 04:18:47; freshness should be verified.

Geography

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