GPX7 Marks Fibroblast-Associated Stromal–Innate Immune Crosstalk in Ulcerative Colitis

A research paper titled 'GPX7 marks fibroblast-associated stromal–innate immune crosstalk in ulcerative colitis' was published by Jingui He on figshare in May 2026. The 132.8 KB PDF integrates Mendelian randomization, transcriptomics, and single-cell RNA sequencing to identify GPX7 as a key marker in ulcerative colitis pathology. It includes validation from a clinical cohort and a fibroblast–macrophage co-culture model.

Use Cases

• Identify genetic candidates in ulcerative colitis based on two-sample Mendelian randomization analysis.
• Analyze stromal–innate immune coupling based on single-cell RNA sequencing localization of GPX7 to a fibroblast state.
• Validate biomarker relevance based on GPX7 expression comparison in infliximab responders versus non-responders.
• Explore candidate drug modulators based on docking and molecular dynamics analyses of QL-X-138.
• Investigate fibroblast–macrophage crosstalk based on transcript amplification results from a Transwell co-culture model.

Strengths

• The study integrates multiple orthogonal methods: Mendelian randomization, cross-cohort transcriptomics, and single-cell RNA sequencing.
• Validation was performed in an independent clinical cohort stratified by infliximab response.
• The file is openly available under a CC-BY-4.0 license.

Limitations

• The dataset is a single PDF document (132.8 KB), not a structured data table; column-level documentation is absent.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.
• Sample data and raw data files are unavailable; the content is a research summary.

Provenance

Source

figshare

Collection Method

Integrated analysis of genetic, transcriptomic, and single-cell data, followed by experimental validation.

Freshness

Last updated 2026-05-22 04:30:51; freshness should be verified.