Gray Matter Volume Correlates Of Psychological Resilience Meta-Analysis

A coordinate-based meta-analysis synthesizes findings from 11 eligible neuroimaging studies involving 2,993 participants. The research identifies a convergent structural correlate of psychological resilience in the medial frontal-cingulate brain architecture. The analysis was performed using MKDA (Multilevel Kernel Density Analysis) with results family-wise error–corrected.

Use Cases

• Validate the identified medial frontal-cingulate hub as a structural biomarker for resilience in new neuroimaging cohorts.
• Correlate individual resilience scores with gray matter volume in the superior and medial frontal gyrus regions identified by the meta-analysis.
• Use the MKDA-derived coordinate convergence maps as a prior for region-of-interest analysis in resilience-focused VBM studies.
• Compare the reported family-wise error–corrected cluster against structural findings from studies on related psychological constructs.

Strengths

• Synthesizes data from 11 independent neuroimaging studies.
• Aggregates findings from a combined sample of 2,993 participants.
• Results are statistically significant (family-wise error–corrected at p < 0.05 with 10,000 permutations).

Limitations

• Modest study base of only 11 eligible studies limits generalizability.
• Variability in definitions and measurements of resilience across the included primary studies.
• The dataset is a 44.8 KB DOCX document containing analysis results, not the underlying raw or coordinate data.

Provenance

Source

figshare, authored by Niki Hosseini-Kamkar.

Collection Method

Coordinate-based meta-analysis of whole-brain voxel-based morphometry studies using MKDA.

Freshness

Last updated March 2026.