Gut Microbiome and Sperm Motility Data from a Human-Mouse Case-Control Study

A case-control study comparing fecal microbiomes of 60 men with isolated asthenozoospermia and 60 healthy controls, published by Yang Pan in 2026. The dataset includes shotgun metagenomic sequencing results, serum metabolomics, and data from fecal microbiota transplantation experiments in germ-free mice. It links gut dysbiosis, specifically depletion of butyrate-producing bacteria, to impaired sperm motility.

Use Cases

• Identify microbial species associated with sperm motility based on metagenomic sequencing data.
• Analyze perturbations in butanoate metabolism pathways using KEGG-enriched metabolite data.
• Model the causal relationship between gut microbiota and sperm quality using fecal microbiota transplantation results.
• Correlate the relative abundance of Faecalibacterium prausnitzii with sperm motility metrics.

Strengths

• Includes data from a matched case-control study with 60 patients and 60 controls.
• Integrates multi-omics data: shotgun metagenomics, untargeted serum metabolomics (39 differential metabolites), and testicular metabolomics (140 differential metabolites).
• Provides causal evidence from fecal microbiota transplantation experiments in germ-free mice.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (219.6 KB), suggesting it contains summary or processed results rather than raw sequencing reads.

Provenance

Source

figshare, authored by Yang Pan.

Collection Method

Shotgun metagenomic sequencing, untargeted and targeted metabolomics, and fecal microbiota transplantation in a case-control study.

Freshness

Last updated 2026-03-18 05:34:31; freshness should be verified.