Gut Microbial IgA Coating in Infants from Farming and Urban Cohorts

Kevin Bu's dataset on figshare contains results from a study of immunoglobulin A (IgA) coating of gut bacteria in infants and its association with allergic outcomes. The data compares 9 infants from a traditional Old Order Mennonite community with a low allergy prevalence (<2%) to 21 infants from an urban Rochester cohort with a higher allergy prevalence (40%). The study used IgA sequencing on stool samples collected at an average of 6 months of life.

Use Cases

• Analyze associations between specific bacterial taxa IgA coating and allergic outcomes based on findings for P. melaninogenica, Pasteurellaceae, and R. gnavus.
• Investigate the relationship between infant age and IgA coating levels based on reported associations with Atopobium, Bifidobacterium, Coprococcus, and Corynebacterium.
• Compare gut microbiome composition and IgA responses between distinct infant populations (traditional farming vs. urban) as described in the background and results.
• Study the role of breastfeeding and human milk IgA-binding capacity on infant fecal IgA levels and commensal bacteria like B. infantis.

Strengths

• Includes data from two distinct infant populations with contrasting allergy prevalences (40% urban vs. <2% traditional farming).
• Study design incorporates multiple assessment methods: IgA sequencing, human milk IgA-binding assays, and in vitro experiments.
• Allergic outcomes were diagnosed and tracked over the first 2 years of life.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small in file size (387.4 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Immunoglobulin A sequencing (IgA-SEQ) performed on infant stool samples, combined with human milk IgA-binding assays and in vitro experiments.

Time Range

Samples collected at an average of 6 months of life; outcomes diagnosed over the first 2 years.

Freshness

Last updated 2026-04-20 05:23:35; freshness should be verified.

Geography

Infants from an urban Rochester cohort and a traditional Old Order Mennonite community.