Gut Microbiota Pathways Linking PSC to Colorectal Cancer

1.1 MB of research data from figshare explores the causal link between primary sclerosing cholangitis (PSC) and colorectal cancer (CRC) risk via gut microbiota. Mendelian randomization analysis suggests a causal association (OR = 1.172) and identifies Lachnospiraceae family and PCBP1 gene as potential mediators. The dataset was authored by Zhaobin He and last updated on April 24, 2026.

Use Cases

• Validate causal links between liver disease and cancer risk based on Mendelian randomization results.
• Investigate the role of Lachnospiraceae family microbes as mediators in disease pathways.
• Analyze PCBP1 gene expression associations with patient survival outcomes in colorectal cancer.
• Integrate microbial and host gene signals for multi-omics studies of the gut-liver axis.

Strengths

• Includes specific statistical results (OR = 1.172, mediating proportion 13.7%) supporting causal inference.
• Data integrates multiple analysis methods: Mendelian randomization, mediation analysis, and single-cell RNA sequencing.
• License is CC-BY-4.0, permitting open reuse and redistribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect methodological bias inherent to the specific genetic and transcriptomic analyses used.

Provenance

Source

figshare

Collection Method

Analysis outputs from Mendelian randomization, mediation, and single-cell RNA sequencing studies.

Freshness

Last updated 2026-04-24 05:39:45; freshness should be verified.