Gut Microbiota Profiles in Anorexia Nervosa Patients and Healthy Controls

30 female patients with anorexia nervosa (AN) and 30 matched healthy controls were compared via 16S rRNA gene sequencing of fecal samples. The study, authored by Meiou Wang and last updated in April 2026, analyzed correlations between microbiota, BMI, disease severity (EDI), and childhood trauma (CTQ). Results showed limited differences in composition and no robust associations with clinical features after statistical correction.

Use Cases

• Compare beta diversity and specific taxon abundances between AN patients and controls based on 16S rRNA sequencing data.
• Investigate nominal correlations between gut microbiota and psychological traits like those measured by the Eating Disorder Inventory (EDI).
• Explore potential, unconfirmed links between microbial profiles and childhood trauma scores from the Childhood Trauma Questionnaire (CTQ).
• Replicate bioinformatics analysis using the QIIME2 pipeline mentioned in the methodology.

Strengths

• Includes matched healthy control group (30 participants).
• Clinical assessments include BMI, EDI, and CTQ scores.
• Data is openly available under a CC-BY-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The study concludes differences were limited and no robust clinical associations were found, indicating exploratory findings.

Provenance

Source

Meiou Wang via figshare

Collection Method

Fecal sample collection and 16S rRNA gene sequencing from a cohort of Chinese female patients and controls.

Time Range

null

Freshness

Last updated 2026-04-15 09:08:47; freshness should be verified.

Geography

Cohort is described as Chinese; specific location is unknown.