Mouse Immune Response Data for COVID-19 Vaccines Under Helminth Infection

A 1.4 MB research document by Jinpeng Su, last updated in May 2026, details a study on vaccine immunogenicity in mice. The work compares mRNA- and protein-based COVID-19 vaccine responses in Schistosoma-infected versus non-infected mice, assessing antibody, CD4, and CD8 T-cell levels. Results indicate both vaccine types conferred effective protection against SARS-CoV-2 challenge despite immune modulation.

Use Cases

• Compare humoral and cellular immune responses based on vaccine platform (mRNA vs. protein) mentioned in the description
• Analyze the impact of a Th2/regulatory-biased immune environment on vaccine-induced CD8 T-cell responses as described
• Evaluate protective efficacy of vaccines based on viral clearance and lung pathology data from the SARS-CoV-2 challenge model
• Study immune modulation by Schistosoma infection on spike-specific antibody titers described in the results

Strengths

• Document is 1.4 MB, indicating a detailed research write-up.
• Study design includes both infected and non-infected control groups, as stated in the methods.
• Results include specific immune metrics: spike-specific antibody, CD4 T-cell, and multifunctional CD8 T-cell responses.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is a single DOCX file; underlying raw data tables are not directly accessible.

Provenance

Source

figshare

Collection Method

Experimental study where mice were immunized and challenged with SARS-CoV-2, with immune responses assessed.

Freshness

Last updated 2026-05-27 20:01:44; freshness should be verified.