Heme Oxygenase-1 Activation in Mononuclear Phagocytes in Acute Kawasaki Disease

A 2026 study by Jieqiong Zeng integrates single-cell and bulk RNA sequencing data to analyze immune cell composition in Kawasaki disease. The dataset likely contains gene expression profiles from peripheral blood mononuclear cells of pediatric patients and a corresponding mouse model. Findings suggest HMOX1 upregulation in mononuclear phagocytes correlates with inflammatory pathway activation.

Use Cases

• Identify gene expression signatures associated with mononuclear phagocyte activation based on scRNA-Seq and bulk RNA-Seq data.
• Validate potential therapeutic targets for Kawasaki disease based on HMOX1 expression levels in clinical and murine model samples.
• Correlate inflammatory cytokine levels, such as tumor necrosis factor-alpha, with specific immune cell states described in the study.

Strengths

• Data integrates both single-cell and bulk RNA sequencing methodologies for cross-validation.
• Includes validation from clinical patient samples and a corresponding murine disease model.
• Dataset is openly licensed under CC-BY-4.0 for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 1.3 MB file size suggests a relatively small dataset, potentially limited to summary-level results.

Provenance

Source

figshare

Collection Method

Single-cell and bulk RNA sequencing of peripheral blood immune cells from Kawasaki disease patients and a CAWS-induced mouse model.

Freshness

Last updated 2026-06-03 05:42:58.