Transcriptomic Zinc Signature and Acute Phase Response in Alcohol-Associated Hepatitis

A nine-gene zinc signature, primarily of metallothionein genes, was derived from 11 publicly available transcriptomic datasets. The data sheet presents findings linking hepatic zinc deficiency to a dampened acute phase response in patients with alcohol-associated hepatitis. The work was authored by Scott A. Read and last updated on 2026-03-18.

Use Cases

• Validate the nine-gene zinc signature in other patient cohorts based on the described transcriptomic signature.
• Investigate the relationship between zinc levels and acute phase response genes like SAA1, CRP, and C9 based on the pathway analysis.
• Model the impact of zinc supplementation on immune response using the in vitro hepatocyte and macrophage data described.

Strengths

• Derived from 11 publicly available transcriptomic datasets, providing a multi-source foundation.
• Includes in vitro validation using primary immune cell and hepatocyte models as described in the methods.
• Published under a permissive CC-BY-4.0 license, allowing for reuse and redistribution.

Limitations

• The core data file is a 3.4 MB DOCX, which may contain processed results rather than raw data tables.
• Row count and column-level documentation are unknown, limiting suitability assessment for direct analysis.
• Data may reflect the specific biases inherent to the 11 source datasets aggregated from figshare.

Provenance

Source

figshare, authored by Scott A. Read.

Collection Method

Bioinformatic analysis of 11 public datasets and in vitro validation with cell cultures.

Freshness

Last updated 2026-03-18 07:36:49.