Histotripsy Treatment Effects on Osteosarcoma in a Mouse Model

Elliana R. Vickers published this dataset on figshare in 2026. It contains results from a study evaluating histotripsy, a non-invasive ultrasound ablation modality, in an orthotopic mouse model of osteosarcoma. The data includes measurements of tumor volume, hemorrhage, contrast enhancement, and survival outcomes for 53 mice across acute and sub-acute time points.

Use Cases

• Modeling tumor volume reduction based on treatment group and initial tumor size mentioned in the description
• Analyzing survival time extension correlated with histotripsy treatment and initial tumor volume
• Evaluating temporal changes in treatment zone involution and contrast enhancement post-therapy
• Comparing acute (1-3 days) and sub-acute (7-14 days) pathological responses to ablation

Strengths

• Data is derived from a controlled study with 53 mice, grouped by initial tumor volume
• Results include statistically significant p-values (e.g., p < 0.0001 for survival) for key outcomes
• Tumor volume changes are quantified with specific percentages (e.g., 74% decrease for treated-small tumors)

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data may reflect bias inherent to a single preclinical mouse model study

Provenance

Source

Elliana R. Vickers via figshare

Collection Method

Experimental data from an orthotopic mouse model study, with outcomes evaluated via MRI and histopathology.

Time Range

Study time points include 1, 3, 7, 14, and up to 30 days post-treatment.

Freshness

Last updated 2026-04-13 04:35:23

Geography

Laboratory setting; specific location not provided.