HLA Allele-Specific TCR Vβ Gene Usage Preferences

Data Sheet 1_HLA alleles shape distinct biases in the usage preferences of TCR Vβ segments.csv contains allele-specific T-cell receptor Vβ gene usage profiles derived from population-scale TCRβ repertoires. The dataset was created by Leonardo V. Castorina and last updated on 2026-05-29. It provides normalized HLA-Vβ preference vectors to quantify germline-driven TCR–HLA compatibility.

Use Cases

• Benchmarking TCR-pHLA specificity prediction methods based on HLA-specific TCR Vβ biases.
• Analyzing the relationship between HLA amino-acid sequence and Vβ gene usage preferences.
• Disentangling HLA positions associated with TCR engagement from those associated with peptide-binding motifs.
• Investigating germline-driven constraints on TCR–HLA compatibility using population-scale repertoire data.

Strengths

• Data is derived from population-scale TCRβ repertoires linked to donor HLA genotypes.
• Uses validated imputation models for HLA genotype inference.
• Normalized preference vectors provide an interpretable measure of HLA-Vβ bias.
• Analysis controlled for CMV exposure to isolate HLA-specific effects.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the specific population-scale repertoires used.

Provenance

Source

Leonardo V. Castorina via figshare

Collection Method

Constructed from population-scale TCRβ repertoires with HLA genotypes inferred using imputation models.

Freshness

Last updated 2026-05-29 08:22:41; freshness should be verified.