Hongjam: Hepatoprotective Effects in a Mouse Model of Metabolic Liver Disease

Hye-Rin Ahn's research paper, published on figshare in May 2026, investigates the effects of Hongjam, an edible silkworm-derived food, on liver disease. The 504.0 KB PDF contains results from a study using a methionine-choline-deficient diet-induced mouse model of metabolic dysfunction-associated steatohepatitis. It includes findings from histological analysis, plasma biochemical assessments, western blotting, quantitative PCR, and in vitro cell experiments.

Use Cases

• Analyze the hepatoprotective effects of food-derived compounds based on histological and biochemical data.
• Study the modulation of TGF-β/Smad and NF-κB signaling pathways in liver disease based on described mechanistic findings.
• Investigate the impact of silk fibroin peptides on inflammatory signaling in macrophages based on in vitro experiment results.
• Evaluate dietary strategies for attenuating metabolic stress and fibrotic remodeling based on the study's conclusions.

Strengths

• The dataset is a detailed research paper with a specific mechanistic focus on TGF-β/Smad and NF-κB signaling pathways.
• It includes results from multiple experimental methods: histological analysis, plasma biochemistry, western blotting, and qPCR.
• The data is openly licensed under CC-BY-4.0, allowing for reuse and redistribution.

Limitations

• The dataset is a single 504.0 KB PDF file; the underlying raw data tables, column definitions, and row counts are unavailable.
• The scope is limited to a specific mouse model (MCD diet-induced) and one intervention (Hongjam), which may limit generalizability.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Hye-Rin Ahn

Collection Method

Experimental study using an MCD diet-induced mouse model, with in vitro validation in macrophages and HepG2 cells.

Freshness

Last updated 2026-05-26 04:39:11; freshness should be verified.