Human Pathological Findings in Kawasaki Disease: A Narrative Review

A narrative review synthesizing human autopsy and biopsy studies on Kawasaki disease from January 1, 1974 to December 31, 2025. The document, authored by Jiaying Zhang, integrates classical histopathology with modern molecular findings to characterize pathological features across cardiovascular and extracardiac systems.

Use Cases

• Reviewing the three-process model of coronary artery involvement in Kawasaki disease based on the description of necrotizing arteritis, subacute/chronic vasculitis, and luminal myofibroblastic proliferation.
• Analyzing extracardiac tissue findings for intracytoplasmic inclusion bodies and IgA plasma cell infiltration to investigate infection-triggered mechanisms.
• Studying key signaling pathways (TLRs/NF-κB, NLRP3/IL-1β, Ca²+/NFAT, TGF-β) and genetic polymorphisms contributing to immune dysregulation and vascular injury.
• Identifying potential therapeutic targets based on the synthesized pathological progression from acute inflammation to chronic vascular remodeling.

Strengths

• The review covers a defined time range of studies from 1974 to 2025.
• It synthesizes findings from both autopsy and biopsy studies, providing integrated insights.
• The document is licensed under CC-BY-4.0, allowing for open reuse.

Limitations

• The dataset is a single 40.1 KB DOCX file, indicating a limited scope and likely a textual review rather than raw data.
• Column-level documentation is absent; the content structure must be inferred after download.
• Row count is unknown, which may limit suitability assessment for quantitative analysis.

Provenance

Source

figshare

Collection Method

A narrative review searching PubMed and Web of Science.

Time Range

January 1, 1974 to December 31, 2025

Freshness

Last updated 2026-05-07 04:44:09.