Human Stem Cell-Derived Neuroepithelial Cells in Chicken Diencephalon Transplant Study

A research paper details an experiment where human pluripotent stem cell-derived neuroepithelial cells were transplanted into chicken embryos. The study demonstrates these cells can develop into an isthmic organizer, driving the formation of a laminated optic tectum. The document is authored by Meghdad Yeganeh and was last updated on June 1, 2026.

Use Cases

• Study the formation of secondary neural organizers based on the described interspecies transplantation model.
• Investigate the acquisition of isthmic organizer properties based on the described molecular expression changes post-transplantation.
• Model human brain development defects based on the described generation of organizers from human pluripotent stem cells.
• Analyze optic tectum lamination based on the described experimental outcome in the chicken diencephalon.

Strengths

• The dataset is a 3.2 MB PDF document providing detailed experimental methodology and findings.
• The data is shared under a CC-BY-4.0 license, allowing for broad reuse with attribution.
• The research addresses a specific gap in studying human secondary organizers due to technical and ethical limitations.

Limitations

• The dataset is a single PDF file; column-level data and sample data are unavailable for direct computational analysis.
• The row count is unknown, which may limit suitability assessment for quantitative modeling.
• The description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Interspecies transplantation experiment described in the research paper.

Freshness

Last updated 2026-06-01 05:18:30; freshness should be verified.