Hyperlipidemia-Induced Tendon Dysfunction: TGF-β/Smad2 Signaling and ECM Remodeling

A 1.2 MB PDF research article by Peiyang Shang, last updated April 17, 2026, and shared under a CC-BY-4.0 license on figshare. It investigates the molecular mechanisms linking hyperlipidemia to tendon extracellular matrix failure, focusing on the TGF-β/Smad2 signaling pathway. The study examines how oxidized lipids disrupt TβRII localization, TGF-β activation, and the balance of collagen synthesis and degradation.

Use Cases

• Analyze the role of TGF-β/Smad2 signaling in tendon homeostasis based on the described molecular pathway.
• Study the impact of oxidized lipids on collagen synthesis and degradation based on Col1a1, LOX, and MMP-1 activity findings.
• Investigate lipid raft localization of TβRII and its effect on TGF-β activation as described in the methods.
• Model metabolic dysregulation's effect on extracellular matrix remodeling based on the described mechanism linking hyperlipidemia to tendon damage.

Strengths

• File size is precisely 1.2 MB.
• License is clearly defined as CC-BY-4.0.
• Author and last update date (2026-04-17) are provided.

Limitations

• The dataset is a single PDF document; row count and column-level data are unknown.
• Description metadata is limited; actual data quality requires manual inspection after download.
• The data is a research article, not a structured dataset for direct computational analysis.

Provenance

Source

figshare, author Peiyang Shang.

Collection Method

Likely contains experimental results from a biomedical study, as described in the article's methods section.

Freshness

Last updated 2026-04-17 04:11:51; freshness should be verified.