Hypobaric Hypoxia Effects on Lung Dendritic and CD4+ T Cells in HAPE Models

Experimental data from a study on high-altitude pulmonary edema (HAPE) using rat and mouse models. The research analyzes the role of lung dendritic cells and CD4+ T cells under hypobaric hypoxia conditions. Findings are based on single-cell sequencing, flow cytometry, and in vitro co-culture methods.

Use Cases

• Analyze the relationship between hypobaric hypoxia exposure and lung dendritic cell recruitment counts from experimental models.
• Investigate CD4+CD25+ T cell proportion changes in response to TNF-α injection or deficiency in HAPE models.
• Model the immunosuppressive phenotype differentiation of T cells mediated by dendritic cells under hypoxic stress.
• Correlate IL-6 production levels with dendritic cell counts in TNF-α-deficient mouse lung tissue.

Strengths

• Data underpins a peer-reviewed research study with specific biological findings on HAPE.
• Experimental validation uses multiple techniques: single-cell sequencing, flow cytometry, and in vitro co-culture.
• Results are derived from controlled animal models (rats and mice) for hypobaric hypoxia.

Limitations

• Dataset is small, contained within a 2.0 MB document file.
• Primary data tables and raw numerical results are not explicitly provided in a structured, machine-readable format.
• Findings are specific to rodent models and may not directly translate to human physiology.

Provenance

Source

Figshare, authored by Xuemei Wei.

Collection Method

Data generated from laboratory experiments on rat and mouse models of high-altitude pulmonary edema.

Freshness

Last updated on 2026-03-24.