Data Sheet 1_Hypsizygus marmoreus polysaccharides protect against cisplatin-induced intest

A 4.3 MB document authored by Mohammed Abusidu details a 2026 study on Hypsizygus marmoreus polysaccharides (HMP). The research investigates HMP's protective effects against cisplatin-induced intestinal mucositis in mice, analyzing antioxidant activity, inflammatory cytokines, and gut microbiota composition via 16S rRNA sequencing. The dataset is licensed under CC-BY-4.0 and was last updated on April 10, 2026.

Use Cases

• Analyzing the relationship between polysaccharide composition and antioxidant activity based on the described ABTS+ radical-scavenging assay results.
• Modeling the impact of HMP on gut microbiota restoration based on the 16S rRNA sequencing data and reported enrichment of beneficial taxa like Akkermansia muciniphila.
• Investigating correlations between HMP treatment and suppression of pro-inflammatory cytokines (IL-1β, IL-6, TNF-α) described in the results.
• Studying the protective mechanisms of natural compounds on intestinal barrier integrity based on the reported tight junction protein and mucin secretion data.

Strengths

• The study provides specific quantitative results, including a 16% HMP extraction yield and a molecular weight of 752.96 kDa.
• In-vivo and in-vitro results are detailed, showing concentration-dependent antioxidant activity and significant alleviation of clinical symptoms in a mouse model.
• The dataset is openly shared under a permissive CC-BY-4.0 license, facilitating reuse and analysis.

Limitations

• The core data (e.g., raw sequencing data, full numerical results) is embedded within a 4.3 MB DOCX file, requiring extraction and may not be in a readily analyzable format.
• Column-level documentation and sample data are unavailable, making the structure and accessibility of the underlying data uncertain.
• The dataset's scale and row count are unknown, which may limit suitability assessment for computational analysis.

Provenance

Source

Mohammed Abusidu via figshare.

Collection Method

Experimental data from a mouse model study, including polysaccharide extraction, antioxidant assays, histopathology, cytokine analysis, and 16S rRNA sequencing.

Time Range

Study details are from 2026, but the specific data collection period is not stated.

Freshness

Last updated 2026-04 10 18:01:14; freshness should be verified.

Geography

The geographical origin of the study or data is not specified.