Icariin-Mediated TNF-α Stabilization and Endothelial Recovery After Myocardial Infarction

A research document from figshare authored by Ce Cao, last updated in May 2026. It details a study investigating the pro-regenerative effects of Icariin (ICA) on endothelial cells in a rat model of heart failure. The work employs bioinformatics, molecular docking, and experimental validation to propose a novel signaling mechanism.

Use Cases

• Analyze the proposed mechanism of TNF-α structural stabilization based on the molecular docking and dynamics simulations described.
• Study the relationship between Icariin and endothelial cell proliferation/migration based on the EdU and wound healing assays mentioned.
• Investigate the TNF signaling pathway's role in cardiac repair based on the bioinformatics and Western blotting results discussed.

Strengths

• Document is under a permissive CC-BY-4.0 license.
• Last update timestamp is precisely recorded (2026-05-08 05:55:14).

Limitations

• The dataset is a 2.1 MB DOCX file; the underlying experimental data (e.g., numerical results, raw images) is not directly accessible.
• Row count and column-level documentation are absent; data structure and semantics must be inferred from the text.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, author Ce Cao.

Collection Method

Experimental research using rat models, cell cultures, bioinformatics, and molecular simulations.

Time Range

Study period not specified; document last updated 2026-05-08.

Freshness

Last updated 2026-05-08 05:55:14; freshness should be verified.

Geography

Not explicitly stated, likely laboratory-based research.