Coxsackievirus A5 Neutralizing Epitopes Identified via Antibody Escape Mutants

A 2026 study by Ke Xu maps conformational neutralizing epitopes on Coxsackievirus A5 (CVA5). The research identifies ten key amino acid sites pivotal for monoclonal antibody recognition using escape mutant analysis and reverse genetics. Findings provide a structural framework for vaccine and antibody-based therapeutic development.

Use Cases

• Designing targeted vaccines based on identified conformational neutralizing epitopes.
• Developing monoclonal antibody therapeutics against Coxsackievirus A5 using the mapped key residues.
• Studying viral capsid structure and antigenic determinants using the ten confirmed key sites.
• Training models for epitope prediction based on the antibody pressure selection methodology.

Strengths

• Identifies ten specific key amino acid sites (K1103, V1215, N1282, F1288, T1291, K2076, E2160, T3059, D3060, E3139) for antibody recognition.
• Provides structural mapping of sites on the viral capsid, distinguishing locations like the southern rim and canyon's northern rim.
• First evidence of multiple conformational neutralizing epitopes on CVA5, offering a novel antigenic basis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is presented in a PDF format (1.5 MB), which may require extraction for computational analysis.

Provenance

Source

figshare

Collection Method

Generated via monoclonal antibody pressure selection, escape mutant analysis, and reverse genetics.

Freshness

Last updated 2026-04-29 05:57:23; freshness should be verified.