IL-4-Mediated Monocyte Differentiation and PRRSV Infection Study

A research article investigates the impact of IL-4 cytokine on monocyte differentiation and its effect on Porcine Reproductive and Respiratory Syndrome Virus infection. The study, authored by Narae Kim and published under CC-BY-4.0 license, includes in vitro and in vivo analyses of immune cell responses. The findings suggest IL-4-mediated programming regulates cellular permissiveness to PRRSV and may contribute to protective host immune responses.

Use Cases

• Study cytokine influence on viral permissiveness based on IL-4 and GM-CSF differentiation protocols described.
• Analyze correlation between CD163 expression and PRRSV replication levels as detailed in the findings.
• Investigate immune cell function modulation based on described TNF-α, IL-6, and IL-10 production post-infection.
• Examine the impact of monocyte differentiation on T-cell proliferation based on described CD8+ T cell assays.

Strengths

• Includes both in vitro monocyte-derived cell experiments and in vivo analysis of infected pigs.
• Examines multiple immune parameters: viral replication, cytokine production, surface marker expression, and T-cell proliferation.
• Published under a permissive CC-BY-4.0 license for reuse.

Limitations

• Dataset consists of a single 242.4 KB PDF file; scale is limited.
• Column-level documentation for any underlying data is absent; field semantics must be inferred from the article.
• Row count for any potential tabular data is unknown, which may limit suitability assessment.

Provenance

Source

Narae Kim

Collection Method

Laboratory research involving porcine monocyte differentiation, viral infection assays, and immune profiling.

Freshness

Last updated 2026-06-04 05:39:56; freshness should be verified.