Immune Architecture of Colorectal Cancer Brain Metastases: 50 Patient Tissue Microarrays

50 patients with colorectal cancer brain metastases, including 31 matched primary tumor–brain metastasis pairs, are analyzed in this dataset. Immunohistochemical analyses of CD68, CD86, CD163, and PD-L1 were performed on tissue microarrays by Lisa Marie Grape, with results last updated in April 2026. The data quantifies compartment-specific tumor-associated macrophage densities and PD-L1 expression to assess heterogeneity and correlate with clinical outcomes.

Use Cases

• Analyze spatial heterogeneity of tumor-associated macrophages based on CD68, CD86, and CD163 staining patterns
• Investigate PD-L1 expression dynamics and discordance between primary tumors and brain metastases
• Correlate macrophage infiltration at the invasive front with brain metastasis–free survival
• Assess the impact of dexamethasone treatment on M1-associated TAM densities in brain metastases

Strengths

• Includes 31 matched primary tumor–brain metastasis pairs, enabling comparative analysis
• Quantifies four specific immunohistochemical markers (CD68, CD86, CD163, PD-L1) across tumor compartments
• Correlates findings with clinicopathological parameters and clinical outcomes like survival

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data is contained in a 381.2 KB PDF, suggesting limited raw data scope and requiring extraction

Provenance

Source

figshare

Collection Method

Immunohistochemical analyses performed on tissue microarrays from tumor specimens.

Time Range

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Freshness

Last updated 2026-04-13 05:45:11

Geography

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