Immune Correlates in Vaccine-Associated Small Fiber Neuropathy: 71 Patient Profiles

71 previously healthy patients with neurological symptoms following SARS-CoV-2 vaccination were studied. The dataset includes results from cutaneous biopsies, peripheral blood sampling for antibody analysis, and flow cytometric analysis, collected by Alessandro Limongelli. The median time from vaccination to symptom manifestation was 3 days, and symptom severity was high at the time of evaluation.

Use Cases

• Analyze immune cell imbalances based on flow cytometric analysis of NKG2D+CD8+ and NKG2D+DNAM-1+CD4+ T-cells
• Correlate symptom severity and onset timing based on patient-reported symptom data and median time from vaccination
• Investigate small fiber neuropathy markers based on reduced small fiber density observed in biopsies
• Compare antibody reactivity profiles based on anti-ACE-2 and NRP-1 antibody ELISA and IF results

Strengths

• 71 patient profiles provide a defined cohort for analysis
• Includes multiple data modalities: biopsy results, antibody assays, and flow cytometry
• Specific temporal data: median symptom onset time of 3 days post-vaccination

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data may reflect bias inherent to a single clinical study on figshare

Provenance

Source

figshare

Collection Method

Clinical study of patients with neurological symptoms post-vaccination, including biopsies and blood sampling.

Time Range

Data collection likely occurred over a period culminating in the study's publication.

Freshness

Last updated 2026-03-19 05:19:28; freshness should be verified