Immune Function in Paediatric Trauma Patients: A Prospective Cohort Study

A prospective explorative cohort study conducted at Radboud University Medical Center between January 2024 and June 2025. It includes 29 participants aged 4–16 years, comprising controls, monotrauma, and polytrauma patients. Immune function was assessed via blood samples at three timepoints to characterize early effects of trauma severity.

Use Cases

• Modeling the relationship between injury severity and immunosuppression based on immune cell counts and functionality.
• Identifying biomarkers for nosocomial infection risk based on plasma concentrations of DAMPs and cytokines.
• Analyzing immune response trajectories over time based on blood samples taken at the trauma scene, emergency room, and post-injury day 1.
• Investigating potential immunomodulation therapies based on ex vivo cytokine production capacity upon stimulation.

Strengths

• Data includes 29 participants across three distinct clinical groups.
• Immune function was measured at three specific timepoints per patient.
• Study protocol was approved by a medical ethics review committee (METC Oost-Nederland, file 2023-16883).

Limitations

• Small sample size of 29 participants, which the authors note requires cautious interpretation.
• Row count and column-level documentation are unknown, limiting suitability assessment.
• Data is contained in a 674.1 KB DOCX file, which may require extraction and structuring.

Provenance

Source

Lotte M. C. Jacobs via figshare.

Collection Method

Prospective explorative cohort study with blood sample collection.

Time Range

January 2024 to June 2025.

Freshness

Last updated 2026-05-20 13:11:51; freshness should be verified.

Geography

Radboud University Medical Center, Netherlands.