Plasmodium-Babesia Co-infection Mouse Study Data and Analysis

664.5 KB of research data and analysis on cross-protection between malaria and babesia parasites in mice. The study by Iqra Zafar, published on figshare under CC-BY-4.0, investigates how a non-lethal Plasmodium infection confers innate immunity against lethal Babesia via macrophage activation. Results include survival rates, parasitemia levels, cytokine profiles, and flow cytometry data from co-infected and immune-depleted mice.

Use Cases

• Analyze macrophage-driven cross-protection mechanisms based on survival and parasitemia data from co-infected mice.
• Model cytokine balance (IFN-γ, IL-12p70, TNF-α, IL-10) and its role in protective homeostasis described in the results.
• Investigate the role of innate immune cells (NK cells, macrophages) in heterologous protection using data from selective depletion experiments.
• Study splenic histopathology and parasite burden correlations with immune responses using qPCR and flow cytometry data mentioned.

Strengths

• Detailed methodological description covering survival, parasitemia, hematology, histopathology, qPCR, cytokine measurement, antibody detection, and flow cytometry.
• Clear experimental design comparing co-infected, SCID, and immune-cell-depleted mouse groups.
• Openly licensed under CC-BY-4.0 for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The primary file format is DOCX, which may require conversion for structured data analysis.

Provenance

Source

figshare

Collection Method

Laboratory study using mouse models, with data collected via survival tracking, parasitemia measurement, hematological analysis, splenic histopathology, qPCR, cytokine/antibody assays, and flow cytometry.

Freshness

Last updated 2026-05-05 04:10:24; freshness should be verified.