Impact of Code Stroke on Andexanet Administration Time in Intracranial Hemorrhage

A single-center retrospective study by Koji Tanaka analyzed 42 patients with factor Xa inhibitor-associated intracranial hemorrhage from May 2022 to May 2025. It compares door-to-andexanet administration times between patients treated with and without a Task Calc. Stroke-based Code Stroke protocol. The study found a statistically significant shorter administration time for the Code Stroke group.

Use Cases

• Analyze the association between Code Stroke activation and door-to-andexanet administration time using multivariable linear regression.
• Compare baseline hematoma volume and arrival during regular hours as adjustment variables in the treatment time analysis.
• Investigate the distribution of primary hemorrhage locations (intracerebral, epidural/subdural, subarachnoid) across the 42-patient cohort.

Strengths

• Study includes 42 patient records with detailed clinical and treatment variables.
• Reports a statistically significant finding (p < 0.01) for the primary outcome of door-to-andexanet time.
• Data covers a defined three-year time range from May 2022 to May 2025.

Limitations

• Very small sample size of 42 patients limits statistical power and generalizability.
• Single-center retrospective design introduces potential selection and information bias.
• Data is presented in a PDF report (136.6 KB), not a structured, machine-readable table for direct analysis.

Provenance

Source

Koji Tanaka via figshare.

Collection Method

Single-center retrospective study.

Time Range

May 2022 to May 2025.

Freshness

Last updated March 2026, indicating recent analysis.

Geography

Single-center location, unspecified.