Stress Hyperglycemia Ratio and Stroke Outcomes in Thrombolysis Patients

A 7.3 KB PDF contains a population-based study investigating the impact of the Stress Hyperglycemia Ratio (SHR) on 90-day functional outcomes in ischemic stroke patients treated with intravenous thrombolysis. The research, conducted by Danhui Li, analyzed data from 36 medical centers and identified a non-linear relationship with a significant threshold effect at SHR = 1.09.

Use Cases

• Analyze the non-linear relationship between the Stress Hyperglycemia Ratio (SHR) and the 90-day modified Rankin Scale score to identify the 1.09 threshold for poor outcomes.
• Validate the SHR's predictive value for functional outcomes in specific patient subgroups, such as non-diabetic patients or those with BMI < 25 kg/m².
• Apply the study's multivariable logistic regression model, adjusting for demographic and clinical parameters, to assess SHR as a risk stratification indicator.

Strengths

• Identifies a specific, actionable threshold (SHR = 1.09) for predicting poor functional outcomes.
• Analysis is based on a multi-center study involving data from 36 medical centers.
• Includes sensitivity analyses in defined subpopulations (non-diabetic, BMI < 25 kg/m², HbA1c < 6.5%).

Limitations

• The dataset is extremely small (7.3 KB), containing only a summary PDF without the underlying tabular patient data.
• Data is retrospective, which may introduce biases not present in a prospective study design.
• The specific sample size (number of patient rows) and individual patient-level variables are not provided in the available metadata.

Provenance

Source

figshare, authored by Danhui Li.

Collection Method

Retrospective enrollment of ischemic stroke patients with intravenous thrombolysis from 36 centers.

Freshness

Last updated March 23, 2026.