Clinical Trial Data on Hemodialysis with Hemoperfusion for Immune and Mitochondrial Health

A clinical study document details a single-center, prospective, self-controlled trial involving 20 maintenance hemodialysis patients. The research investigated the effects of combining hemoperfusion with high-flux hemodialysis on T lymphocyte subsets, mitochondrial membrane potential, and patient-reported outcomes over 12 treatment sessions. The document was authored by Qi Zhong and last updated on 2026-05-21.

Use Cases

• Analyzing changes in T lymphocyte subsets (CD3+, CD4+, CD8+) based on combined hemodialysis and hemoperfusion treatment.
• Investigating the relationship between protein-bound uremic toxin clearance (indoxyl sulphate, p-cresyl sulphate) and immune parameters.
• Evaluating patient-reported outcomes like sleep quality (PSQI), pruritus, and quality of life (SF-36) following a specific dialysis intervention.
• Studying mitochondrial health in T cells via mitochondrial membrane potential measurements in a clinical cohort.

Strengths

• The dataset is associated with a structured clinical trial involving 20 patients with pre- and post-intervention measurements.
• It includes multiple specific outcome measures: levels of protein-bound uremic toxins, T cell subsets, mitochondrial membrane potential, and three patient-reported outcome scales.
• The document provides detailed statistical results (p-values) for changes in clinical and laboratory parameters.

Limitations

• The dataset is a 787.0 KB DOC file; the underlying structured data format and column definitions are unknown.
• The study design is a single-arm, observational trial, which the authors note is hypothesis-generating and lacks a control group.
• Row count for any potential underlying data tables is unknown, which may limit suitability assessment.

Provenance

Source

figshare, author Qi Zhong.

Collection Method

Data likely originates from a single-center, prospective, self-controlled clinical trial.

Time Range

The trial period involved 12 treatment sessions administered every 2 weeks.

Freshness

Last updated 2026-05-21 04:19:23; freshness should be verified.