In Vitro Inhibition of Streptococcus Mutans by Cardamom Essential Oil

Cardamom essential oil demonstrated the strongest inhibition of Streptococcus mutans growth and biofilm formation among twelve tested oils. This dataset contains results from agar diffusion, broth microdilution, biofilm, and cell viability assays, along with qPCR analysis of six virulence genes. The data was authored by Nanki J. Singh and last updated on May 11, 2026.

Use Cases

• Compare the antibacterial potency of natural products based on minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) data.
• Analyze the effect of essential oils on biofilm formation based on crystal violet assay results.
• Investigate bacterial stress responses based on the upregulation of virulence-associated genes (gtfB, gtfC, gtfD, ldh, gbpB, vicR) measured via qPCR.
• Evaluate the potential of cardamom essential oil as an anticariogenic agent based on in vitro assays against the primary cariogenic bacterium.

Strengths

• Specific minimum inhibitory (2.5% v/v) and bactericidal (5.0% v/v) concentrations are reported.
• Biofilm formation and cell viability decreased by more than 75% at 5.0% concentration.
• Analysis includes six specific virulence-associated genes (gtfB, gtfC, gtfD, ldh, gbpB, vicR).

Limitations

• The dataset is small (157.3 KB), indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Nanki J. Singh via figshare

Collection Method

Laboratory assays including agar well diffusion, broth microdilution, crystal violet biofilm assay, MTT cell viability assay, and quantitative PCR.

Freshness

Last updated 2026-05-11 05:28:14; freshness should be verified.