B-Cell and Cytokine Profiles in 272 ART-Treated HIV Patients with EBV Coinfection

272 patients living with HIV from Hospital Universitario San Ignacio in Bogotá, Colombia, were analyzed for B lymphocyte subpopulations, immunoglobulin isotypes, cytokines, and EBV viral load. The dataset, authored by Niyireth Peñaloza and last updated in March 2026, shows associations between incomplete B-cell reconstitution, persistent inflammation, and EBV-linked lymphoma progression. Data was collected using next-generation flow cytometry, multiplex cytokine assays, and quantitative PCR.

Use Cases

• Modeling the relationship between B-cell subpopulation depletion and HIV clinical stage based on flow cytometry data.
• Analyzing cytokine profiles (e.g., MIP-1β, G-CSF, IL-6) associated with persistent inflammation in HIV patients.
• Investigating the impact of EBV coinfection and time on ART on humoral memory loss and immature B-cell phenotypes.
• Correlating immunological markers with clinical outcomes such as AIDS-defining diseases and lymphoma progression.

Strengths

• Includes data from 272 patients, providing a substantive cohort for analysis.
• Multimodal laboratory measurements: flow cytometry for B cells, multiplex assays for cytokines, and PCR for EBV viral load.
• Patients are categorized by clinical stage, disease category, time on ART, and EBV coinfection status, enabling stratified analysis.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• Data is from a single hospital in Colombia, which may limit generalizability to other populations.
• The dataset is small at 23.2 KB, indicating limited scope and likely summary-level or aggregated data.

Provenance

Source

Hospital Universitario San Ignacio, Bogotá, Colombia.

Collection Method

Clinical and laboratory analysis of patient samples using flow cytometry, multiplex assays, and PCR.

Freshness

Last updated 2026-03-18 05:21:10

Geography

Bogotá, Colombia.