Influenza Vaccination Outcomes in High-Risk Populations: An Umbrella Review

An umbrella review synthesizing evidence from 14 systematic reviews and meta-analyses on influenza vaccination for high-risk populations. The evidence base covers more than 230 million participants, with data gathered from PubMed, Embase, and the Cochrane Library up to December 1, 2025. The review was authored by Chengyan Jin and published on figshare in 2026.

Use Cases

• Assessing the association between influenza vaccination and major adverse cardiovascular events based on the review's findings for ischemic heart disease.
• Evaluating the impact of vaccination on COPD exacerbations based on the described respiratory outcomes.
• Analyzing the safety profile of influenza vaccination based on the reported lack of clear increase in serious adverse events.
• Comparing evidence certainty for different outcomes like stroke based on the described heterogeneity and mixed study designs.

Strengths

• Synthesizes evidence from 14 systematic reviews and meta-analyses.
• Evidence base covers more than 230 million participants.
• Methodological quality was assessed using AMSTAR-2 and evidence certainty using GRADE.
• Explicitly addresses review overlap using citation matrices and corrected covered area (CCA).

Limitations

• The dataset is a 24.1 KB DOCX document, indicating a very limited scope and likely a summary report rather than raw data.
• Row count and column-level documentation are absent; field semantics must be inferred from the narrative text.
• Freshness should be verified; the last update was 2026-05-26, which is a future date relative to the current time.

Provenance

Source

figshare, author Chengyan Jin

Collection Method

Umbrella review of systematic reviews and meta-analyses identified through PubMed, Embase, and the Cochrane Library.

Time Range

Reviews from database inception to December 1, 2025.

Freshness

Last updated 2026-05-26 06:02:11