Innate Immune Profiling Data for Hypertension in Male Subjects

A study profiling peripheral blood mononuclear cells from 10 hypertensive and 10 normotensive male subjects using mass cytometry, with validation in an independent cohort of 16 subjects. The dataset, authored by Xiaoqi Wang and last updated in April 2026, focuses on the reduction of a specific CD57+CD62L+CD161+ natural killer cell subpopulation in hypertensive patients with cytomegalovirus exposure.

Use Cases

• Identify immune cell subsets associated with hypertension based on high-dimensional CyTOF and flow cytometry data.
• Analyze transcriptional heterogeneity within a specific NK cell population based on single-cell RNA sequencing results.
• Investigate the mechanistic link between IL-15 signaling and NK cell survival/apoptosis in hypertension based on described gene expression patterns.
• Validate biomarker discovery for hypertensive immune dysregulation based on the described reduction of the CD57+CD62L+CD161+ NK subpopulation.

Strengths

• Data is validated across two independent cohorts totaling 36 male subjects.
• Employs three complementary high-resolution techniques: mass cytometry (CyTOF), full-spectrum flow cytometry, and single-cell RNA sequencing.
• License is permissive (CC-BY-4.0) for reuse and redistribution.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• Data is limited to male subjects, which may restrict generalizability.
• The dataset is small (3.8 MB), which may indicate limited raw data or processed summaries only.

Provenance

Source

figshare

Collection Method

High-dimensional mass cytometry (CyTOF), full-spectrum flow cytometry, and single-cell RNA sequencing of peripheral blood mononuclear cells from human subjects.

Time Range

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Freshness

Last updated 2026-04-16 05:25:49; freshness should be verified.

Geography

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