Data Sheet 1_Insights into the effects of gut microbiota and circulating metabolites on or

Mendelian randomization analysis identified 35 gut microbial taxa and 20 circulating metabolites with causal links to oral cancer. The dataset includes results from genome-wide association studies for 471 microbial taxa, 233 metabolites, and oral cancer, validated with clinical multi-omics samples. Author Junfeng Guo published the findings on figshare in May 2026.

Use Cases

• Validate causal microbiome-disease links based on Mendelian randomization results
• Investigate metabolite mediation pathways based on identified mediators like citrate and omega-3 fatty acids
• Replicate GWAS-based associations for oral cancer risk factors
• Design clinical validation studies based on the multi-omics profiling approach described

Strengths

• Analysis includes data from 471 gut microbial taxa and 233 circulating metabolites
• Results validated with clinical multi-omics profiling samples
• Employs multiple Mendelian randomization methods (IVW-MR, GSMR) with tests for pleiotropy and heterogeneity

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Data may reflect bias inherent to the specific GWAS sources used

Provenance

Source

Genome-wide association studies (GWAS) for gut microbiota, circulating metabolites, and oral cancer

Collection Method

Bidirectional two-sample Mendelian randomization analysis with clinical validation

Freshness

Last updated 2026-05-21 05:45:51; freshness should be verified