Renal Tubulocystic Oncocytoma: Integrated Clinicopathological and Genomic Profile

A 2026 study by Wenchi Wang provides a genomic and immunophenotypic characterization of a single case of renal tubulocystic oncocytoma (RTO). The analysis includes whole-exome sequencing results identifying 399 somatic SNVs and 91 INDELs, alongside immunohistochemistry and tumor microenvironment profiling. The data is shared as a document under a CC-BY-4.0 license.

Use Cases

• Identify potential driver mutations in rare renal tumors based on the 27 candidate driver genes reported.
• Characterize an 'immune-cold' tumor microenvironment phenotype based on low densities of immune cell markers.
• Validate diagnostic markers for renal oncocytoma based on positive IHC staining for CD117, EMA, and E-cadherin.
• Perform drug-target prediction analysis based on variants with potential therapeutic relevance identified in the study.

Strengths

• Whole-exome sequencing data from a pathologically confirmed case, identifying 399 somatic SNVs and 91 INDELs.
• Immunohistochemistry results for multiple diagnostic markers and tumor microenvironment cell types.
• Includes a literature-based comparative analysis with eight previously reported RTO cases.

Limitations

• Data is based on a single case study, limiting statistical power and generalizability.
• The primary data is embedded in a DOCX document, requiring manual extraction for computational analysis.
• Column-level documentation for any underlying structured data is absent.

Provenance

Source

Wenchi Wang via figshare.

Collection Method

Whole-exome sequencing, immunohistochemistry, and literature review of a single case.

Freshness

Last updated 2026-04-14 04:14:22.