Data Sheet 1_Integrated multi-omics profiling reveals phenotype- and tissue-specific host-

A 2026 study by Anqi Wang presents integrated transcriptomic and shotgun metagenomic sequencing data from paired tumoral and peritumoral mucosal tissues of 88 advanced gastric cancer patients from Northwest China. The dataset includes 8870 differentially expressed genes and profiles of differentially abundant bacterial species, revealing phenotype- and tissue-specific host-microbe interactions. The work aims to fill a critical gap in multi-omics research for this population.

Use Cases

• Identify host gene expression signatures distinguishing tumor from peritumoral tissue based on the 8870 differentially expressed genes.
• Analyze correlations between host gene expression and specific bacterial species like Serratia surfactantfaciens or Pseudomonas protegens.
• Investigate transcriptomic signatures associated with Lauren classification subtypes (intestinal, diffuse, mixed) in gastric cancer.
• Study the impact of Helicobacter pylori infection on host gene expression pathways in peritumoral tissues.

Strengths

• Includes data from 88 patients, providing a substantial clinical cohort.
• Features paired samples from both tumoral and peritumoral tissues for within-patient comparison.
• Integrates two omics layers: host transcriptomics and microbial metagenomics.
• Analysis identifies 8870 differentially expressed genes and 13199 significant host-microbe correlations.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is from a specific geographic region (Northwest China), which may limit generalizability.

Provenance

Source

Anqi Wang via figshare.

Collection Method

Transcriptomic and shotgun metagenomic sequencing of clinical tissue samples.

Time Range

Study published in 2026; specific sample collection period is not stated.

Freshness

Last updated 2026-04-20 05:23:12; freshness should be verified.

Geography

Northwest China.