Integrated Network Pharmacology and In Vivo Evidence for Vitamin E's Multi-Organ Effects

34 core genes were identified linking acute lung injury, secondary enteritis, and vitamin E through integrated database screening and protein-protein interaction analysis. The research, authored by Jinhai Shao and last updated in March 2026, presents findings from an LPS-induced mouse model, demonstrating vitamin E's protective effects on lung and intestinal barriers. The 782.1 KB PDF document offers molecular insights and a scientific basis for nutritional-immunomodulatory intervention.

Use Cases

• Identify shared therapeutic targets for multi-organ injury based on the 34 identified core genes.
• Study macrophage polarization dynamics in acute lung injury based on the described modulation of M1/M2 states.
• Investigate neutrophil recruitment in systemic inflammation based on the evidence of its suppression.
• Explore molecular commonalities between lung and intestinal pathologies based on the described systematic delineation.
• Model the lung-intestine axis for nutritional intervention strategies based on the proposed scientific basis.

Strengths

• Identifies 34 specific core genes linking the studied conditions.
• Integrates multiple analytical methods: GeneCards database screening, PPI network, and pathway analyses.
• Provides in vivo evidence from an LPS-induced mouse model.
• Released under a permissive CC-BY-4.0 license.

Limitations

• The dataset is a 782.1 KB PDF, which is a small document format requiring manual extraction of structured data.
• Column-level documentation and sample data are unavailable, limiting immediate suitability assessment.
• The data is derived from a specific mouse model, which may limit direct applicability to human systems.

Provenance

Source

Jinhai Shao via figshare.

Collection Method

Integrated computational database screening and experimental validation in a mouse model.

Time Range

The study's temporal coverage is not specified.

Freshness

Last updated 2026-03-18 05:21:21.

Geography

The study's geographic coverage is not specified.