Data Sheet 1_Integrated stress response genes as novel biomarkers and therapeutic targets in ankylosing spondylitis: a transcriptomic and Mendelian randomization study.xlsx

A transcriptomic and Mendelian randomization study identifies candidate biomarkers and therapeutic targets for Ankylosing Spondylitis. The research includes differentially expressed genes like RORA, FBXO31, and MSRB3, validated via RT–qPCR in clinical blood samples. It provides analysis results on causal associations, functional enrichment, immune infiltration, and drug predictions.

Use Cases

• Analyze the causal contributions of ISR-related genes like RORA, FBXO31, and MSRB3 to AS risk using Mendelian randomization results.
• Investigate correlations between identified biomarker expression levels and immune cell infiltration, particularly Th1 cells and keratinocytes.
• Explore drug prediction results linking candidate biomarkers to potential therapeutic agents such as indirubin and pentoxifylline.
• Validate transcriptomic profiling findings of differentially expressed genes in peripheral blood from AS patients with clinical sample data.

Strengths

• Includes results from multiple analytical methods: transcriptomic profiling, Mendelian randomization, functional enrichment, and drug prediction.
• Candidate biomarkers RORA, FBXO31, and MSRB3 were validated in clinically collected blood samples via RT–qPCR.
• Dataset is openly shared under a CC BY 4.0 license, facilitating reuse and redistribution.

Limitations

• The dataset is very small at 27.3 KB, indicating limited raw data or summary-level results rather than extensive primary data.
• Specific row counts, column names, and sample data are unavailable, limiting detailed reproducibility and direct analysis.
• Geographic origin and sample size of the clinical validation cohort are not specified, which may affect generalizability.

Provenance

Source

Shuai Wang via figshare.

Collection Method

Transcriptomic profiling of peripheral blood from AS patients, Mendelian randomization analysis, followed by functional enrichment, immune infiltration, drug prediction, and RT–qPCR validation.

Time Range

null

Freshness

Last updated March 2026.

Geography

null