Psoriasis Vulgaris Comorbidity Network Analysis via Ising Model and Multiomics

A research document analyzing the comorbidity network of psoriasis vulgaris using large-scale retrospective cohort data and the Ising model. The study identifies atherosclerosis-coronary heart disease as the core comorbidity and explores shared molecular mechanisms via proteomics and metabolomics. The work, authored by Dongwen Shi and last updated in April 2026, includes a prospective intervention study on IL-17A inhibition.

Use Cases

• Model disease comorbidity networks based on the Ising model methodology described.
• Identify key hub comorbidities based on network centrality metrics like degree and betweenness.
• Investigate shared molecular pathways based on multiomics evidence including proteomics and lipid peroxidation metabolomics.
• Evaluate therapeutic intervention impacts based on the prospective study of IL-17A inhibition.

Strengths

• Analysis based on large-scale retrospective cohort data.
• Integrates clinical, proteomic, and metabolomic evidence.
• Includes a prospective intervention study for clinical validation.
• Licensed under CC-BY-4.0 for open reuse.

Limitations

• The dataset is a 19.6 KB DOCX file, indicating a limited scope of raw data.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare, author Dongwen Shi.

Collection Method

Constructed from large-scale retrospective cohort data and a prospective intervention study.

Time Range

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Freshness

Last updated 2026-04-14 05:28:49; freshness should be verified.

Geography

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