Integrative Multi-Omics Analysis of SNRPE in Uterine Corpus Endometrial Carcinoma

A 15.9 MB research document published on figshare in May 2026 by Minyue Cao. It presents a multi-omics study identifying SNRPE as a key driver gene in uterine corpus endometrial carcinoma (UCEC). The work integrates GWAS, sQTL, eQTL, RNA-seq, and scRNA-seq data to link splicing dysregulation to tumor progression and immune evasion.

Use Cases

• Identifying prognostic biomarkers for UCEC based on the described SNRPE association with survival outcomes.
• Studying the link between splicing factor dysregulation and immune evasion based on the described MHC-I and MDK signaling findings.
• Analyzing the structural impact of alternative splicing events on oncogenic pathways based on the described analysis of PAK1, SOS1, PIK3CB, and IL17RC.

Strengths

• Data is derived from established sources like the TCGA-UCEC cohort and validated with an independent clinical cohort.
• The study integrates multiple high-throughput data types, including GWAS, RNA-seq, and scRNA-seq.
• Functional validation was performed using in vitro assays and a doxycycline-inducible xenograft model.

Limitations

• The primary data file is a 15.9 MB DOCX document; underlying raw datasets are not directly provided.
• Row and column counts for any associated data tables are unknown, limiting suitability assessment.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare

Collection Method

Integrative analysis of public genomics data (e.g., TCGA) combined with original experimental validation.

Time Range

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Freshness

Last updated 2026-05-21 05:42:22.

Geography

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