Integrin Beta3 Deficiency Multi-Omics Data for Pulmonary Inflammation

2026-03-24 data from a study on spontaneous pulmonary inflammation in constitutive β3-deficient mice. The dataset includes integrated transcriptomic and proteomic profiling of lung tissue, with analyses linking reduced ITGB3 expression to B cell activation via the CD40-CD40L axis. It is a 5.2 MB ZIP file containing multi-omics data from murine models and patient transcriptomics.

Use Cases

• Analyze transcriptomic signatures of B cell activation in lung tissue from β3-deficient mice.
• Integrate proteomic and transcriptomic profiles to identify molecular drivers of spontaneous pulmonary inflammation.
• Correlate murine multi-omics data with patient transcriptomics data to validate ITGB3 expression links to autoimmune disease signatures.
• Investigate CD40-CD40 Ligand axis engagement and NF-κB pathway hyperactivation from the integrated profiling data.

Strengths

• Includes integrated multi-omics data (transcriptomics and proteomics) from a controlled murine model.
• Data is linked to patient transcriptomics from autoimmune disease patients for translational validation.
• Released under a permissive CC BY 4.0 license for broad reuse.

Limitations

• Small dataset size of 5.2 MB suggests limited sample depth or scope.
• Specific row and column counts, sample sizes, and data granularity are unknown from the description.
• Focus is on a specific murine genetic model (β3−/−), limiting generalizability to other conditions.

Provenance

Source

Figshare, authored by Shuang Liu.

Collection Method

Generated from histopathology, integrated transcriptomic/proteomic profiling of lung tissue, and functional assays in β3-deficient mice, with validation using patient transcriptomics data.

Time Range

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Freshness

Last updated on 2026-03-24.

Geography

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