Interleukin-40 Biomarker Data for Severe Pneumonia Mortality Risk, 2023-2025

From May 2023 to May 2025, this dataset includes serum interleukin-40 (IL-40) levels and clinical outcomes for 104 patients with severe pneumonia, 50 with non-severe pneumonia, and 86 healthy controls. It was created by Hong Tan and shared on figshare under a CC-BY-4.0 license to investigate IL-40 as a predictor of 28-day mortality. The data likely contains patient measurements at ICU admission, including IL-40 levels, SOFA scores, and survival status.

Use Cases

• Predicting 28-day mortality risk in severe pneumonia patients based on IL-40 levels at ICU admission.
• Evaluating the prognostic performance of IL-40 combined with SOFA scores using AUC metrics.
• Analyzing survival curves to compare patient groups with IL-40 levels above and below the 1.244 ng/mL threshold.

Strengths

• Includes a defined cohort of 240 total participants (104 severe pneumonia, 50 non-severe pneumonia, 86 healthy controls).
• Provides a specific IL-40 concentration threshold (1.244 ng/mL) associated with poorer survival (p=0.001).
• Reports quantitative performance metrics, such as an AUC of 0.7626 for IL-40 alone and 0.7980 when combined with SOFA score.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (632.5 KB), indicating limited scope and sample size.

Provenance

Source

figshare

Collection Method

Clinical study enrolling patients and measuring serum IL-40 levels at ICU admission.

Time Range

May 2023 to May 2025

Freshness

Last updated 2026-05-27 20:01:42; freshness should be verified.