Data Sheet 1_Intrahost viral evolution of SARS-CoV-2 infections in rheumatic versus hemato

26 severely immunocompromised patients with COVID-19 were studied for intrahost viral evolution. The dataset likely contains results from virome sequencing, phylogenetic analysis, and intrahost single nucleotide variants (iSNVs) analysis, identifying unique mutations in the spike gene. It was authored by Emmanouil Karofylakis and last updated on 2026-04-30.

Use Cases

• Analyze the accumulation of intrahost single nucleotide variants (iSNVs) based on infection duration mentioned in the results.
• Compare viral mutation profiles between rheumatic and hematologic patient groups based on the study's findings.
• Investigate the prevalence of rare mutations in the spike, RdRP, and 3CLPro genes based on the sequencing results.
• Study correlations between B-cell depletion, prior infection/vaccination status, and clinical outcomes like hospitalization and mortality based on patient cohort data.

Strengths

• Includes data from 26 patients with detailed clinical characteristics (median age 71, 88% treated with B-cell depleting agents).
• Reports a statistically significant iSNVs accumulation with a calculated average substitution rate per site per day of 7 × 10⁻⁶.
• Identifies 30 mutations in the spike gene and 6 unique mutations in polymerase/protease genes from sequenced samples.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is small (631.9 KB), reflecting a limited cohort of 26 patients from a single study.
• Data may reflect temporal and clinical bias inherent to the specific observational study design.

Provenance

Source

figshare, author Emmanouil Karofylakis

Collection Method

Prospective observational study with SARS-CoV-2 virome sequencing on respiratory samples, followed by phylogenetic and iSNVs analysis.

Freshness

Last updated 2026-04-30 04:17:43; freshness should be verified.