Meta-Analysis of Vitamin D vs. Triamcinolone for Keloid Treatment

A 2026 meta-analysis by Dan Jiang compares the efficacy and safety of intralesional vitamin D versus triamcinolone acetonide for keloid treatment. The analysis includes four randomized controlled trials sourced from PubMed, Embase, and Cochrane. It reports primary outcomes on scar improvement and secondary outcomes on lesion flattening and adverse events.

Use Cases

• Compare treatment efficacy for scar regression based on the reported mean difference in scar severity scores.
• Assess relative safety profiles based on the reported risk ratios for adverse events like pigmentation changes and skin atrophy.
• Inform clinical decision-making for patients concerned about steroid-related side effects, based on the described safety outcomes.
• Guide future research on alternative keloid therapies based on the synthesized evidence from four randomized controlled trials.

Strengths

• Focuses on a direct clinical comparison between two treatments for a specific condition.
• Reports specific statistical results, including mean differences and risk ratios with confidence intervals.
• Uses a systematic review methodology, sourcing data from three major medical databases.

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download.
• Row count is unknown, which may limit suitability assessment.
• The evidence base is described as limited, with only four trials included.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of randomized controlled trials.

Freshness

Last updated 2026-06-03 04:47:13; freshness should be verified.