Intravitreal AAV Vector Delivery: Ocular Inflammation and Immune Response Markers

A 2026 research article by Helena Costa-Verdera, published on figshare under a CC-BY-4.0 license, details immune responses to retinal gene therapy. The 6.1 MB PDF describes transcriptomic and functional assay data from porcine and mice models treated with the AAV2.7m8 vector. The work identifies markers like MCP-1, IP-10, and complement C3a, and explores the role of integrins in inflammation.

Use Cases

• Analyzing antiviral interferon response pathways based on transcriptomic data mentioned in the description
• Studying complement activation and DNA damage markers like C3a and γH2AX in transduced retinas
• Modeling gene therapy-associated uveitis (GTAU) based on cytokine levels (MCP-1, IP-10, MIP-1α, IL-6) and microglial activation
• Investigating the role of integrins in mediating peripheral leukocyte infiltration during intravitreal delivery

Strengths

• Includes transcriptomic analysis data from animal models
• Identifies specific inflammatory markers (MCP-1, IP-10, MIP-1α, IL-6, C3a, γH2AX)
• Published under a permissive CC-BY-4.0 license

Limitations

• The primary data format is a PDF (6.1 MB); underlying raw datasets are not directly accessible
• Row count and column-level documentation are unknown, limiting suitability assessment
• Data may reflect bias inherent to the specific animal models and experimental conditions used

Provenance

Source

figshare

Collection Method

Experimental data from porcine and mice models, including transcriptomic analysis and functional assays.

Freshness

Last updated 2026-04-22 05:49:24