Mouse Model of Radiosurgery-Induced Hearing Loss with Dose and Time Response Data

31 C57BL/6J mice were irradiated with doses from 8 to 32 Gy to establish a model of stereotactic radiosurgery-induced unilateral hearing loss. Auditory brainstem response thresholds and cochlear histology were measured at baseline and at 1, 4, and 16 weeks post-treatment. The dataset likely contains dose-dependent and time-dependent measurements of hearing loss and cochlear damage.

Use Cases

• Modeling dose-dependent hearing loss based on radiation dose groups (8, 16, 24, 32 Gy)
• Analyzing progressive hearing decline based on auditory brainstem response measurements at multiple time points
• Investigating cochlear damage mechanisms based on histological analysis of hair cells, ribbon synapses, and spiral ganglion neurons

Strengths

• Includes specific, statistically significant results, such as outer hair cell reductions of 14% and 44% at 4 weeks for 32 Gy
• Describes a controlled experimental design with multiple dose groups (n=3,5,8,15) and longitudinal follow-up
• Data is associated with a published research methodology using the Leksell Gamma Knife ICON system

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Experimental data from a study establishing a mouse model of radiation-induced hearing loss.

Freshness

Last updated 2026-05-07 04:44:37; freshness should be verified