Chronic Ketamine and Inulin Effects on Gut Microbiota and Behavior in a Rodent Model

Figshare hosts a research data sheet by Zhilong Xu, uploaded in April 2026, detailing an experimental study on chronic ketamine exposure and inulin intervention in rodents. The document analyzes effects on anxiety-like behaviors, spatial learning, memory, gut microbiota composition, and related biochemical pathways. It provides detailed methodological and results data from the controlled animal study.

Use Cases

• Analyze correlations between gut microbiota abundance (e.g., Colidextribacter, Lachnospiraceae_NK4A136_group) and behavioral scores for anxiety and spatial memory.
• Model the relationship between short-chain fatty acid (SCFA) levels in serum, hippocampus, and feces and the expression of synaptic proteins Syn and PSD-95.
• Investigate the BDNF-TrkB-ERK1/2-CREB signaling pathway data to understand its role in ketamine-induced neuronal damage and inulin-mediated recovery.
• Examine prepulse inhibition (PPI) deficit data alongside gut permeability metrics to explore gut-brain connectivity in a schizophrenia-like model.

Strengths

• Study includes a 28-day chronic exposure timeline, providing longitudinal data on intervention effects.
• Multifaceted data covers behavioral assays, microbial taxonomy, biochemical levels (SCFAs, BDNF), and histopathological markers.
• Document is openly licensed under CC-BY-4.0, facilitating reuse and analysis.

Limitations

• Dataset is a 13.1 MB DOCX file, not a structured data table, requiring manual extraction for computational analysis.
• Sample size (number of animal subjects) is not specified in the provided metadata.
• Data is from a single controlled animal study, limiting generalizability to human populations.

Provenance

Source

Zhilong Xu via the figshare repository.

Collection Method

Data generated from a controlled laboratory experiment using rodent models, involving behavioral testing, tissue sampling, and biochemical analysis.

Time Range

Experimental period involved 28 days of ketamine exposure and intervention.

Freshness

Last updated April 2026, indicating recent research.