Hepatitis E Virus Seroprevalence in Alzheimer's Disease Patients, 453 Cases

A single-center retrospective case-control study of 453 cognitively impaired adults from southern Germany, comparing anti-HEV IgG seropositivity between patients with Alzheimer's disease and those with non-AD cognitive impairment. The dataset was created by Tiberiu Daniel Capraru and last updated on 2026-05-07. Results indicate an overall HEV IgG seroprevalence of 44.5% in the AD group versus 37.7% in the non-AD group.

Use Cases

• Assessing the association between Hepatitis E virus exposure and Alzheimer's disease based on anti-HEV IgG seropositivity data.
• Performing age-stratified statistical analyses on seroprevalence differences between patient groups, as described in the study.
• Training models to evaluate candidate environmental risk factors for dementia using case-control study data.

Strengths

• Includes data from 453 patient records, providing a substantive sample size for analysis.
• Study design includes multivariable logistic regression and age-stratified analyses, as mentioned in the description.
• Specific seroprevalence percentages are reported for different age groups (e.g., 46.5% vs. 35.1% for ages 60-69).

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• Data is from a single center in southern Germany, which may reflect geographic bias.
• The primary data file is a 214.6 KB DOCX document, suggesting the underlying structured data may require extraction.

Provenance

Source

figshare, author Tiberiu Daniel Capraru

Collection Method

Single-center retrospective case-control study

Freshness

Last updated 2026-05-07 05:34:32; freshness should be verified.

Geography

Southern Germany