Data Sheet 1_Investigation of the active compounds and pharmacological mechanisms of Qufen

A research document details the investigation of Qufengxuanfei Decoction's mechanism for treating chronic cough. The study identified 207 intersecting drug-disease targets and validated findings through molecular docking and animal experiments on guinea pigs. The 38.7 KB DOCX file was authored by Zhilin Liu and last updated on 2026-04-30.

Use Cases

• Identifying potential drug targets for chronic cough based on the 207 intersecting targets identified.
• Validating molecular interactions for compounds like quercetin and tanshinone IIA using the described docking results.
• Analyzing gene enrichment for airway neurogenic inflammation using the 838 biological processes and 179 KEGG pathways mentioned.
• Designing follow-up animal studies on cough sensitivity using the described guinea pig model and evaluation metrics.

Strengths

• The study methodology is detailed, combining network pharmacology with in vivo animal experiments.
• Specific results are provided, including 6 key bioactive compounds and 12 core gene targets like TP53 and TNF.
• The document is shared under a permissive CC-BY-4.0 license.

Limitations

• The dataset is a 38.7 KB DOCX file; the underlying raw data (e.g., gene lists, experimental measurements) is not directly provided in a structured format.
• Row count and column-level documentation are absent, requiring manual extraction of data from the text.
• Freshness should be verified as the last update date is in the future (2026-04-30).

Provenance

Source

figshare, authored by Zhilin Liu.

Collection Method

Data was generated through computational network pharmacology analysis and laboratory animal experiments.

Freshness

Last updated 2026-04-30 05:38:43; freshness should be verified.