Irisin and Microglial Inflammation: Molecular Pathway Analysis from an In Vitro Study

A 159.2 KB PDF document authored by Roberta Mancuso, last updated on 2026-04-23. The document describes an in vitro study investigating the anti-inflammatory effects of the myokine irisin on β-amyloid-induced human microglial activation, focusing on microRNA-mediated regulation of the TLR4/NLRP3 inflammasome pathway.

Use Cases

• Analyzing molecular pathways related to neuroinflammation based on the described TLR4/NLRP3 axis.
• Studying microRNA expression patterns (e.g., miR-451a, miR-223-3p) in cell models based on the described assays.
• Investigating the role of exercise-related factors like irisin in modulating microglial responses based on the study's mechanistic insights.

Strengths

• The dataset is openly licensed under CC-BY-4.0.
• The description provides specific details on experimental methods, including digital droplet PCR and flow cytometry.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The data is contained in a single 159.2 KB PDF, which is a very small and limited scope.

Provenance

Source

figshare, author Roberta Mancuso

Collection Method

In vitro laboratory study using human immortalized microglia (hTERT) cells.

Time Range

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Freshness

Last updated 2026-04-23 04:19:13; freshness should be verified.

Geography

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